The KULT manifesto

We're not wrong.
We're early.

Health care, not sick care. Comprehensive labs, mitochondria, hormones, gut, lowest effective dose. With the evidence attached, footnote by footnote.

We are inevitable · Healing · Optimization · Health care, not sick care · Proactive health is not a crime · We are inevitable · Healing · Optimization · Health care, not sick care · Proactive health is not a crime ·
I. The thesis

Health care.
Not sick care.

We are inevitable. Not because we are loud. Because the biology is on our side, the data is on our side, and the bill for doing it the old way has come due.

Mainstream medicine is built to catch you when you fall. Excellent at it. Nobody runs a trauma bay like the American hospital. But it has almost nothing to offer the forty-year-old who is tired, thick around the middle, sleeping badly and "within normal limits" on every test the system bothered to order. That person is told to come back when something breaks.

We think that is backwards. We look at the whole panel, not one number. We treat the systems that generate energy, signal, and defense before we treat the disease those systems fail into. We use the lowest dose that works, cycle what should be cycled, and measure everything.1

Proactive health is not a crime. It only feels like one because nobody has figured out how to bill for a hospital visit that never happens.

II. The labs

One TSH is not a thyroid panel.

The boards will tell you a full thyroid panel is unnecessary. Order a TSH; if it is normal, stop.2 We say your metabolic function is everything, and a single pituitary signal cannot describe it.

TSH tells you what the pituitary thinks. It does not tell you how much active hormone is reaching your cells, how well you convert T4 to T3, or whether your immune system is attacking the gland. The pituitary's relationship to circulating T3 is not fixed; it shifts with age, illness, and treatment, which is exactly why a "normal" TSH can sit on top of a patient who feels terrible.3 Free T3, free T4, reverse T3, TPO and thyroglobulin antibodies cost a few dollars more and change the decision.

The same argument runs through the whole panel. We do not care about your total testosterone. What is your free testosterone, your bioavailable fraction, your SHBG, your IGF-1? The Endocrine Society's own guideline says to measure free testosterone whenever SHBG might be abnormal, which in a metabolically stressed adult is most of the time.4 A ten-dollar boron supplement lowered SHBG and raised free testosterone in a week in a published trial, and we have the before-and-after labs to show it in practice.5

Your A1c is fine? Look at your fasting insulin. Hyperinsulinemia precedes the diagnosis of type 2 diabetes by a decade or more; by the time glucose fails, the pancreas has been compensating for years.6 We treat the insulin, not the eventual glucose. Microdose a GLP-1. Lose the weight slowly. Build the habits. Then taper: a Scripps Clinic case series moved patients from weekly injections to every two weeks, some to every six, and they held their weight, body composition, and metabolic gains for an average of nine months.7

Total testosterone. Free, bioavailable, SHBG, IGF-1.

The number the specialist quotes is the least useful one on the page.

A1c is normal. Fasting insulin is 22.

The fire alarm works. The building has been on fire for eight years.

TSH is 2.1, you're fine. Free T3 is at the floor.

The signal is normal. The delivery is not.

III. The protocol

Mitochondria. Hormones. Gut.

The first three steps in our process. Completely neglected by specialists, because no specialty owns them.

Optimize mitochondria. They are not just the power plant. They are a signaling organelle that tells the rest of the cell how to respond to stress, and mitochondrial function tracks with nearly every age-related decline we care about.8 Light, cold, heat, sleep, and load are the first prescription. The pharmacology comes after.

Balance hormones. Measured properly, replaced physiologically, at the lowest effective dose, monitored on a schedule.4 Rhythmic, not flat, for women. Free fraction, not total, for men.

Strengthen the gut. The microbiome sits upstream of metabolic health, immune tone, and the inflammation that ages you.9 Fix the barrier, feed the bugs, then talk about supplements.

Evidence-based medicine, as its founders defined it, is the integration of the best available research with clinical expertise and the patient in front of you.10 That is our operating system. Lowest effective dose. Cycle supplements so receptors stay sensitive. Strengthen all eleven systems of the body, not the one that happens to be complaining.11

01 · MITOCHONDRIA

Energy and signal.

Sunlight first, then cold, heat, sleep and load. NAD+ precursors, methylene blue, urolithin and the peptides when the fundamentals are in place and the labs say so.

02 · HORMONES

Measured, then moved.

Full thyroid, full sex-hormone, full adrenal panels. Free fractions and binding globulins. Boron before Big Pharma. Replacement only when the numbers and the symptoms agree.

03 · GUT

Barrier, bugs, bile.

Stool testing when it changes the plan. Fiber, fermentation, glutamine, BPC-157 under the registry. Then, and only then, the supplement stack.

IV. The fundamentals

Get STARTED.

Super human protocols for a super toxic world. Seven ancestral pillars, borrowed from The Cockroach Diet, that make you very hard to kill.

Choose your adversity, or life will choose it for you. The cheat codes come out only when the basics do not suffice.

SSunlightQuantum photons. Reset your clock.
TTemperanceDitch the toxins. Upgrade mitochondria.
AAirBreathwork. Go outside and play.
RRestSacred wind-down. Pitch-black sleep.
TTrustPray. Reflect. Feed the soul.
EExerciseMove every day. Lift. Sprint. Carry.
DDietAncestral food. Fewer chemicals.
V. The question

So why does healing you feel illegal?

Because our goal is to keep you out of the hospital, away from the surgery you did not need, and off the drug you were going to be on for life.

Nobody's quarterly earnings go up when that works. So the model that does it gets called fringe. Alternative. Borderline. The practitioners who do it get audited before they get studied.

Mainstream medicine and Big Pharma will come around. AI will find cures for rare diseases and reverse aspects of aging. Both of those things are true, and both will happen as soon as someone finds a way to monetize them.

In the meantime, we are KULT. Because healing and optimizing patients, thoroughly enough that you hardly need to come back, is apparently crazy.

VI. The company we keep

Every one of them was crazy first.

The pattern is old enough to have a name. First it is heresy. Then it is obvious. Then everyone claims they always knew.

1633

Galileo Galilei

Tried by the Roman Inquisition for teaching that the Earth moves around the Sun. Forced to recant, kept under house arrest until he died. He was right.12

1847

Ignaz Semmelweis

Cut maternal deaths on his ward from roughly one in ten to about one in a hundred by making doctors wash their hands. The medical establishment ridiculed him. He died in an asylum. He was right.13

1984

Barry Marshall

Said ulcers were caused by a bacterium, not stress. Laughed out of the room, so he drank a culture of it and gave himself gastritis to prove the point. Nobel Prize, 2005. He was right.14

We're not wrong. We're early.

VII. Join

This is not medicine.
It's a movement.

Sign-up takes five minutes. The work takes as long as you want it to. Dive in as little or as much as you like; the plan is yours either way.

Sign the intake.

One form: the medical consent, the Private Membership Association agreement, and the separate, independently revocable consent for the IRB-overseen registry (PPRN-001-2025). Decline the registry and you are still treated.15

5 minutes

Drag and drop your history.

Old labs, imaging, the list of what you take and what you have already tried. PDFs, photos, whatever you have. We read all of it.

Same day

We order comprehensive labs.

The full panel, not the screening panel. Drawn at a lab near you. Typically covered by insurance; if it is not, you will know the cost before the needle.

Drawn locally

We email you the plan.

Written by a licensed clinician. What we found, what it means, what we are doing first, what we are deliberately not doing yet. Reconstitution videos where they apply. Nothing is prescribed by an algorithm, and sometimes the plan is that nothing is prescribed.

Clinician's call

Do your homework.

STARTED is the homework. The cheat codes come after. Your clinician stays reachable between visits, and your labs are re-checked on a schedule set by your numbers, not the calendar.

Ongoing

Clinical care is delivered by licensed clinicians through Mortensen Medical, a 501(c)(3), and its network. Registry protocol PPRN-001-2025 · IRB IRCM-2025-467.

Endnotes

Read the evidence.

  1. Sackett, D. L., Rosenberg, W. M., Gray, J. A., Haynes, R. B., & Richardson, W. S. (1996). Evidence based medicine: What it is and what it isn't. BMJ, 312(7023), 71–72. https://doi.org/10.1136/bmj.312.7023.71
  2. American Society for Clinical Pathology. (2013). Choosing Wisely: Don't order multiple tests in the initial evaluation of a patient with suspected thyroid disease. Order thyroid-stimulating hormone (TSH), and if abnormal, follow up with additional evaluation. ABIM Foundation. https://www.choosingwisely.org; see also Jonklaas, J., et al. (2014). Guidelines for the treatment of hypothyroidism. Thyroid, 24(12), 1670–1751. https://doi.org/10.1089/thy.2014.0028
  3. Hoermann, R., Midgley, J. E. M., Larisch, R., & Dietrich, J. W. (2015). Homeostatic control of the thyroid–pituitary axis: Perspectives for diagnosis and treatment. Frontiers in Endocrinology, 6, 177. https://doi.org/10.3389/fendo.2015.00177
  4. Bhasin, S., Brito, J. P., Cunningham, G. R., Hayes, F. J., Hodis, H. N., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., Wu, F. C., & Yialamas, M. A. (2018). Testosterone therapy in men with hypogonadism: An Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology & Metabolism, 103(5), 1715–1744. https://doi.org/10.1210/jc.2018-00229
  5. Naghii, M. R., Mofid, M., Asgari, A. R., Hedayati, M., & Daneshpour, M. S. (2011). Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. Journal of Trace Elements in Medicine and Biology, 25(1), 54–58. https://doi.org/10.1016/j.jtemb.2010.10.001 (10 mg/day for one week: free testosterone rose, SHBG and estradiol fell, in eight healthy men.)
  6. DeFronzo, R. A. (2009). From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus. Diabetes, 58(4), 773–795. https://doi.org/10.2337/db09-9028; Crofts, C., Zinn, C., Wheldon, M., & Schofield, G. (2015). Hyperinsulinemia: A unifying theory of chronic disease? Diabesity, 1(4), 34–43. https://doi.org/10.15562/diabesity.2015.19
  7. Wong, C., et al., & Biermann, M. (2026). Reduced-frequency GLP1 therapy maintains weight, body composition, and metabolic syndrome improvements: A case series. Obesity. Advance online publication. https://doi.org/10.1002/oby.70137 (Scripps Clinic; 30 patients on tirzepatide or semaglutide moved from weekly to every-two-week, some every-six-week, dosing; weight, body composition, A1c and blood pressure held and HDL improved over a mean 36 weeks.)
  8. Picard, M., & Shirihai, O. S. (2022). Mitochondrial signal transduction. Cell Metabolism, 34(11), 1620–1653. https://doi.org/10.1016/j.cmet.2022.10.008
  9. Fan, Y., & Pedersen, O. (2021). Gut microbiota in human metabolic health and disease. Nature Reviews Microbiology, 19(1), 55–71. https://doi.org/10.1038/s41579-020-0433-9
  10. Sackett et al. (1996), as in note 1. "The conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients."
  11. Betts, J. G., et al. (2013). Anatomy and Physiology (Ch. 1.2, Structural organization of the human body: the eleven organ systems). OpenStax, Rice University. openstax.org
  12. Finocchiaro, M. A. (Ed. & Trans.). (1989). The Galileo affair: A documentary history. University of California Press.
  13. Best, M., & Neuhauser, D. (2004). Ignaz Semmelweis and the birth of infection control. Quality and Safety in Health Care, 13(3), 233–234. https://doi.org/10.1136/qshc.2004.010918
  14. Marshall, B. J., & Warren, J. R. (1984). Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. The Lancet, 323(8390), 1311–1315. https://doi.org/10.1016/S0140-6736(84)91816-6; Nobel Assembly at Karolinska Institutet. (2005). The Nobel Prize in Physiology or Medicine 2005. nobelprize.org
  15. Peptide Pure Research Network. (2025). Site participant consent, Protocol PPRN-001-2025, IRB IRCM-2025-467. https://peptidepure.com/irb-consent. The IRB approved the collection of data. It did not approve, endorse, or evaluate any product, dose, or protocol.

This page is a statement of philosophy, not medical advice. Every treatment decision is made by a licensed clinician with the individual patient after history, examination and laboratory review; some patients are told that treatment is not appropriate. Nothing here describes any compound as approved by the FDA for the uses discussed. Dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure or prevent any disease. Registry participation is voluntary, separate from care, and is not a selling point for any product. Insurance coverage of laboratory testing depends on your plan. If you are experiencing a medical emergency, call 911.